Methoxsalen: Uses, Safety, Dosage and FAQs

When working with Methoxsalen, a synthetic psoralen that makes skin more sensitive to ultraviolet A (UVA) light, commonly used to treat psoriasis, vitiligo and other skin disorders. Also known as 8-MOP, it is the key ingredient in PUVA therapy, a treatment that pairs the drug with controlled UVA exposure. As a type of psoralen, Methoxsalen works by intercalating into DNA and forming cross‑links when activated by UVA, slowing down rapid skin cell growth. The therapy is especially helpful for conditions like vitiligo, where repigmentation is needed, and for stubborn psoriasis plaques that haven’t responded to topical creams.

Methoxsalen is taken orally a few hours before a UVA session, allowing the drug to reach peak blood levels. Typical adult dosing ranges from 0.2 to 0.6 mg/kg, adjusted based on skin type and treatment response. Because the drug makes skin highly photosensitive, users must wear protective eyewear during exposure to prevent eye damage. Liver function should be checked before starting therapy and monitored regularly, as the compound is processed primarily by the liver. Common side effects include nausea, headache, and temporary skin redness; serious reactions like severe burning or blistering signal the need to stop treatment immediately. Proper timing of UVA exposure, usually 2–3 hours after ingestion, ensures the drug is active when the light hits the skin, which is why PUVA therapy requires careful scheduling and a knowledgeable provider.

Below you’ll find a curated collection of articles that dive deeper into Methoxsalen’s role in skin health. We cover practical dosing guides, safety checklists, comparison of PUVA with newer light‑based treatments, and tips for managing side effects. Whether you’re starting therapy, looking for ways to combine Methoxsalen with other skin‑care routines, or simply want to understand the science behind psoralen‑UVA interactions, the posts ahead provide clear, actionable information. Explore the resources to get a complete picture of how Methoxsalen fits into modern dermatology and what you can do to make the most of your treatment plan.